Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mammalian RNase H2 removes ribonucleotides from DNA to maintain genome integrity

16 Jul 2012

Abstract excerpt

Ribonucleases H (RNases H) are endonucleases which cleave the RNA moiety of RNA/DNA hybrids. Their function in mammalian cells is incompletely understood. RNase H2 mutations cause Aicardi-Goutières syndrome, an inflammatory condition clinically overlapping with lupus erythematosus. We show that RNase H2 is essential in mouse embryonic development. RNase H2-deficient cells proliferated slower than control cells...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytokine Signaling Pathways and Interactions
Share to interferon and immune responses
Share to RNA Research and Splicing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22802351
DOI: 10.1084/jem.20120876

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mammalian RNase H2 removes ribonucleotides from DNA to maintain genome integrityPMID 22802351Read ↗

RNase H2, mutated in Aicardi‐Goutières syndrome, resolves co-transcriptional R-loops to prevent DNA breaks and inflammationSemantic proximity Read ↗

Defective removal of ribonucleotides from DNA promotes systemic autoimmunitySemantic proximity Read ↗

Ribonuclease H2 in health and diseaseSemantic proximity Read ↗

Ribonucleotide Excision Repair Is Essential to Prevent Squamous Cell Carcinoma of the Skin.Semantic proximity Read ↗

The structure of the mammalian RNase H2 complex provides insight into RNA.NA hybrid processing to prevent immune dysfunction.Semantic proximity Read ↗

Construction and characterization of ribonuclease H2 C subunit-knockout NIH3T3 cells.Semantic proximity Read ↗

RNase H2 roles in genome integrity revealed by unlinking its activities.Semantic proximity Read ↗

Absence of RNase H2 triggers generation of immunogenic micronuclei removed by autophagy.Semantic proximity Read ↗

Analysis of ribonucleotide content in the genomic DNA of ribonuclease H2 A subunit (RH2A)-knockout NIH3T3 cells after transient expression of wild-type RH2A or RH2A variants with an Aicardi-Goutières syndrome-causing mutation.Semantic proximity Read ↗

Epithelial RNase H2 Maintains Genome Integrity and Prevents Intestinal Tumorigenesis in MiceSemantic proximity Read ↗

RNase H2, mutated in Aicardi‐Goutières syndrome, promotes LINE‐1 retrotranspositionSemantic proximity Read ↗

Human RNase H2 upregulation counteracts oncogene- and chemotherapy-induced replication stressSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.