Article
Human Nuclease/Helicase DNA2 Alleviates Replication Stress by Promoting DNA End Resection
9 Apr 2012
Abstract excerpt
In precancerous and cancerous lesions, excessive growth signals resulting from activation of oncogenes or loss of tumor suppressor genes lead to intensive replication stress, which is recognized by a high level of replication-associated DNA double-strand breaks (DSB). However, the molecular mechanism by which cells alleviate excessive replication stress remains unclear. In this study, we report that the human...
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