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Epigenetic and Transcriptomic Alterations Precede Amyloidosis in the Hippocampus of the Alzheimer’s Disease <i> App <sup>NL-G-F</sup> </i> Knock in Mouse Model

2025-02-21

Abstract excerpt

<h4>ABSTRACT</h4> Detecting and understanding the early stages of Alzheimer’s disease (AD) is essential for uncovering initial mechanisms of neuropathology and devising effective interventions. In this study, we leveraged the humanized App NL-G-F mouse which exhibits early-onset amyloid pathology with a predictable timeline, to investigate molecular changes in the hippocampus and blood before the onset of sever...

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Literature Corpus work
4cc57319-9a58-50a6-b24f-cafaa5bc970b
DOI
10.1101/2025.02.20.639336
Open publication

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Epigenetic and Transcriptomic Alterations Precede Amyloidosis in the Hippocampus of the Alzheimer’s Disease <i> App <sup>NL-G-F</sup> </i> Knock in Mouse ModelDOI 10.1101/2025.02.20.639336
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