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Article

Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer's disease.

Nature - 19 Feb 2015

Gjoneska Elizabeta, Pfenning Andreas R, Mathys Hansruedi, Quon Gerald, Kundaje Anshul, Tsai Li-Huei, Kellis Manolis

Abstract excerpt

Alzheimer's disease (AD) is a severe age-related neurodegenerative disorder characterized by accumulation of amyloid-β plaques and neurofibrillary tangles, synaptic and neuronal loss, and cognitive decline. Several genes have been implicated in AD, but chromatin state alterations during neurodegeneration remain uncharacterized. Here we profile transcriptional and chromatin state dynamics across early and late...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25693568
DOI: 10.1038/nature14252
PMCID: PMC4530583

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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