Article

Methylomic signatures of tau and amyloid-beta in transgenic mouse models of Alzheimer’s disease neuropathology

2025-07-31

Abstract excerpt

Alzheimer’s disease (AD) is characterized by progressive neurodegeneration driven by tau and amyloid-β (Aβ) pathology. Emerging evidence implicates a role for epigenetic modifications, particularly altered DNA methylation (DNAm), in AD pathogenesis. However, few studies have comprehensively investigated DNAm in experimental models. Here, we profile DNAm dynamics in two widely used transgenic mouse models of tau (r...

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Literature Corpus work: 3dada88c-b5c3-5c9f-b741-a25e75f60947
DOI: 10.1101/2025.07.28.666515

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