Article

Selective neuronal vulnerability in Alzheimer’s disease: a network-based analysis

2018-12-19

Abstract excerpt

A major obstacle to treating Alzheimer’s disease (AD) is our lack of understanding of the molecular mechanisms underlying selective neuronal vulnerability, which is a key characteristic of the disease. Here we present a framework to integrate high-quality neuron-type specific molecular profiles across the lifetime of the healthy mouse, which we generated using bacTRAP, with postmortem human functional genomics an...

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Literature Corpus work: 4b1fd6a0-eeb7-57cc-b544-e28e0fc1f4b5
DOI: 10.1101/499897

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