Article

Epigenetic Shifts Reveal Alzheimer’s Origins after Sustained Picomolar Aβ Exposure

2025-08-15

Abstract excerpt

Recent advances in sequencing have identified genetic risk factors for Alzheimer’s disease (AD), but the molecular mechanisms triggering disease onset remain unclear. While high brain levels of amyloid-beta (Aβ) impair synaptic function and memory, exposure to low picomolar (pM) Aβ concentrations - typical of healthy brains - enhances these functions, while sustained exposure results in impairment. To investigate...

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Literature Corpus work: 273e4dd4-05e5-55d3-b355-b11608612b9d
DOI: 10.1101/2025.08.12.668749

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