Article

A disease-associated PPP2R3C-MAP3K1 phospho-regulatory module controls centrosome function

2024-04-03

Abstract excerpt

<h4>Summary</h4> Centrosomes have critical roles in microtubule organization and in cell signaling. 1–8 However, the mechanisms that regulate centrosome function are not fully defined, and thus how defects in centrosomal regulation contribute to disease is incompletely understood. From functional genomic analyses, we find here that PPP2R3C, a PP2A phosphatase subunit, is a distal centriole protein and functional...

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Literature Corpus work: 4ca1cd71-9263-585f-869f-5365cc6e3675
DOI: 10.1101/2024.04.02.587836

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