Article
Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.
Cell reports - 22 Nov 2016
St-Denis Nicole, Gupta Gagan D, Lin Zhen Yuan, Gonzalez-Badillo Beatriz, Veri Amanda O, Knight James D R, Rajendran Dushyandi, Couzens Amber L, Currie Ko W, Tkach Johnny M, Cheung Sally W T, Pelletier Laurence, Gingras Anne-Claude
Abstract excerpt
Reversible phosphorylation is a fundamental regulatory mechanism, intricately coordinated by kinases and phosphatases, two classes of enzymes widely disrupted in human disease. To better understand the functions of the relatively understudied phosphatases, we have used complementary affinity purification and proximity-based interaction proteomics approaches to generate a physical interactome for 140 human...
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