Article

PLK4 homodimerization is required for CEP152 centrosome localization and spindle organization

2023-11-07

Abstract excerpt

<h4>ABSTRACT</h4> Polo-Like Kinase 4 (PLK4) is a unique serine/threonine kinase family member that homodimerizes using its cryptic polo-box (CPB) region. Homodimerization of PLK4 causes transphosphorylation, which activates its ubiquitin-mediated degradation. Interestingly, CPB is also involved in interaction with the upstream centrosome recruiters, CEP152 and CEP192 in human cells. However, the effect of PLK4 ho...

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Literature Corpus work: ede1ec72-64f9-50bb-92fc-05d2595107ee
DOI: 10.1101/2023.11.06.565834

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