Article

Protein phosphatase 1 down regulates ZYG-1 levels to limit centriole duplication

2016-12-12

Abstract excerpt

In humans perturbations of centriole number are associated with tumorigenesis and microcephaly, therefore appropriate regulation of centriole duplication is critical. The C. elegans homolog of Plk4, ZYG-1, is required for centriole duplication, but our understanding of how ZYG-1 levels are regulated remains incomplete. We have identified the two PP1 orthologs, GSP-1 and GSP-2, and their regulators I-2 szy-2 and...

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Literature Corpus work: 47211cd2-6bc1-5660-a26f-4e52710d0daa
DOI: 10.1101/093492

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