Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The PP1 regulator PPP1R2 coordinately regulates AURKA and PP1 to control centrosome phosphorylation and maintain central spindle architecture.

BMC molecular and cell biology - 25 Nov 2020

Bresch Alan-Michael, Yerich Nadiya, Wang Rong, Sperry Ann O

Abstract excerpt

BACKGROUND: Maintenance of centrosome number in cells is essential for accurate distribution of chromosomes at mitosis and is dependent on both proper centrosome duplication during interphase and their accurate distribution to daughter cells at cytokinesis. Two essential regulators of cell cycle progression are protein phosphatase 1 (PP1) and Aurora A kinase (AURKA), and their activities are each regulated by the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aurora Kinase A
Share to Cell Nucleus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Centrosome

Share to Cytokinesis

Share to Ploidies

Share to Protein Phosphatase 1

Share to Proteins

Share to Spindle Apparatus

Source

Open in PubMed Open full text

Identifiers

PMID: 33238888
DOI: 10.1186/s12860-020-00327-5
PMCID: PMC7687763

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The PP1 regulator PPP1R2 coordinately regulates AURKA and PP1 to control centrosome phosphorylation and maintain central spindle architecture.PMID 33238888Read ↗

A Cancer-Associated Missense Mutation in PP2A-Aα Increases Centrosome Clustering during MitosisSemantic proximity Read ↗

A cancer-associated missense mutation in PP2A-Aα increases centrosome clustering during mitosisSemantic proximity Read ↗

A disease-associated PPP2R3C-MAP3K1 phospho-regulatory module controls centrosome functionSemantic proximity Read ↗

Arpc1b, a centrosomal protein, is both an activator and substrate of Aurora A.Semantic proximity Read ↗

PPP2R2A prostate cancer haploinsufficiency is associated with worse prognosis and a high vulnerability to B55α/PP2A reconstitution that triggers centrosome destabilizationSemantic proximity Read ↗

CKAP2 phosphorylation by CDK1/cyclinB1 is crucial for maintaining centrosome integrity.Semantic proximity Read ↗

Centrosome depletion rewires mitosis to impose dependence on the AURKA–TPX2 axisSemantic proximity Read ↗

Protein Kinase D2 Modulates Cell Cycle By Stabilizing Aurora A Kinase at CentrosomesSemantic proximity Read ↗

Hamartin, the tuberous sclerosis complex 1 gene product, interacts with polo-like kinase 1 in a phosphorylation-dependent manner.Semantic proximity Read ↗

Investigating how ubiquitin-mediated proteolysis of AURKA contributes to its activity in the cell cycleSemantic proximity Read ↗

Gain-of-function mutations of Ptpn11 (Shp2) cause aberrant mitosis and increase susceptibility to DNA damage-induced malignancies.Semantic proximity Read ↗

The PP2A subunit PR130 is a key regulator of cell development and oncogenic transformationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.