Article
Genetic interaction between PLK1 and downstream MCPH proteins in the control of centrosome asymmetry and cell fate during neural progenitor division.
Cell death and differentiation - 1 Aug 2022
González-Martínez José, Cwetsch Andrzej W, Gilabert-Juan Javier, Gómez Jesús, Garaulet Guillermo, Schneider Paulina, de Cárcer Guillermo, Mulero Francisca, Caleiras Eduardo, Megías Diego, Porlan Eva, Malumbres Marcos
Abstract excerpt
Alteration of centrosome function and dynamics results in major defects during chromosome segregation and is associated with primary autosomal microcephaly (MCPH). Despite the knowledge accumulated in the last few years, why some centrosomal defects specifically affect neural progenitors is not clear. We describe here that the centrosomal kinase PLK1 controls centrosome asymmetry and cell fate in neural...
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