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Article

The tumor suppressor CDKN3 controls mitosis

17 Jun 2013

Abstract excerpt

Mitosis is controlled by a network of kinases and phosphatases. We screened a library of small interfering RNAs against a genome-wide set of phosphatases to comprehensively evaluate the role of human phosphatases in mitosis. We found four candidate spindle checkpoint phosphatases, including the tumor suppressor CDKN3. We show that CDKN3 is essential for normal mitosis and G1/S transition. We demonstrate that...

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PMID: 23775190
DOI: 10.1083/jcb.201205125

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