Article

A cancer-associated missense mutation in PP2A-Aα increases centrosome clustering during mitosis

2019-03-07

Abstract excerpt

A single incidence of whole-genome doubling (WGD) is common early in tumorigenesis. In addition to increasing ploidy, WGD doubles centrosome number. In the ensuing mitoses, excess centrosomes form a multipolar spindle, resulting in a lethal multipolar cell division. To survive, cells must cluster centrosomes into two poles to allow a bipolar cell division. Cancer cells are typically more proficient at centrosome c...

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Literature Corpus work: e729f68d-29a2-5456-b824-a37d44bddd91
DOI: 10.1101/570978

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