Article

PGRMC1 effects on metabolism, genomic mutation and CpG methylation imply crucial roles in animal biology and disease

2020-03-03

Abstract excerpt

<title>Abstract</title> <p>Background: Progesterone receptor membrane component 1 (PGRMC1) is often elevated in cancers, and exists in alternative states of phosphorylation. A motif centered on PGRMC1 Y180 was evolutionarily acquired concurrently with the embryological gastrulation organizer that orchestrates vertebrate tissue differentiation. <h4>Results:</h4> Here, we show that mutagenic manipulation of PGRMC1...

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Literature Corpus work: e006e14c-68d0-540e-b163-61922ed9ac7d
DOI: 10.21203/rs.2.20008/v2

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