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A Cancer-Associated Missense Mutation in PP2A-Aα Increases Centrosome Clustering during Mitosis

17 Jul 2019

Abstract excerpt

Whole-genome doubling (WGD) is common early in tumorigenesis. WGD doubles ploidy and centrosome number. In the ensuing mitoses, excess centrosomes form a multipolar spindle, resulting in a lethal multipolar cell division. To survive, cells must cluster centrosomes to allow bipolar cell division. Cancer cells are often more proficient at centrosome clustering than untransformed cells, but the mechanism behind...

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PMID: 31357169
DOI: 10.1016/j.isci.2019.07.018

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