Article

Targeting APE1 endonuclease activity impairs metastasis and enhances genotoxic therapy response in pancreatic cancer

2025-12-16

Abstract excerpt

<title>Abstract</title> <p> <bold>Background</bold> Pancreatic ductal adenocarcinoma (PDAC) is a highly deadly cancer with limited treatment options. The base excision repair (BER) pathway, crucial for fixing DNA abasic sites, is driven by apurinic/apyrimidinic endonuclease 1 (APE1). While APE1’s redox function has been extensively studied, its endonuclease activity in PDAC homeostasis and therapeutic response...

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Literature Corpus work: 57936ec9-2d1b-5cb9-aaac-a8d652c516e6
DOI: 10.21203/rs.3.rs-8197122/v1

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