Article

Targeting DNA Damage Response and Replication Stress in Pancreatic Cancer

2019-07-24

Abstract excerpt

<h4>ABSTRACT</h4> Continuing recalcitrance to therapy cements pancreatic cancer (PC) as the most lethal malignancy, which is set to become the second leading cause of cancer death in our society. We interrogated the transcriptome, genome, proteome and functional characteristics of 61 novel PC patient-derived cell lines to define novel therapeutic strategies targeting the DNA damage response (DDR) and replication...

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Literature Corpus work: 2b3c3d3a-190b-5ef6-9001-8cd759cb6287
DOI: 10.1101/713545

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