Article

TRIP13 protects pancreatic cancer cells against intrinsic and therapy-induced DNA replication stress

2025-01-27

Abstract excerpt

<h4>ABSTRACT</h4> Oncogene activation in normal untransformed cells induces DNA replication stress and creates a dependency on DNA Damage Response (DDR) mechanisms for cell survival. Different oncogenic stimuli signal via distinct mechanisms in every cancer setting. The DDR is also pathologically re-programmed and deployed in diverse ways in different cancers. Because mutant KRAS is the driver oncogene in 90% of...

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Literature Corpus work: 68d633b8-456b-5d6c-a1e0-af8bce55eaa3
DOI: 10.1101/2025.01.26.634889

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