Article

Therapeutic Targeting of Oncogene-induced Transcription-Replication Conflicts in Pancreatic Ductal Adenocarcinoma

2023-10-06

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Purpose</h4> Transcription-replication conflicts (TRCs) are a major source of endogenous replication stress in cancer. We previously discovered that pancreatic ductal adenocarcinoma (PDAC) demonstrates uniquely high levels of TRCs compared to other common solid tumors. Here, we characterize the mechanism of action, oncogene-dependency, PDAC subtype-specificity, and preclinical activity of a T...

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Literature Corpus work: 127b5394-872b-5abb-ba53-0721a4f3c92c
DOI: 10.1101/2023.10.03.23296487

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