Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Emerging Role of Cytidine Deaminase in Human Diseases: A New Opportunity for Therapy?

Molecular therapy : the journal of the American Society of Gene Therapy - 5 Feb 2020

Frances Audrey, Cordelier Pierre

Abstract excerpt

The recycling activity of cytidine deaminase (CDA) within the pyrimidine salvage pathway is essential to DNA and RNA synthesis. As such, CDA deficiency can lead to replicative stress, notably in Bloom syndrome. Alternatively, CDA also can deaminate cytidine and deoxycytidine analog-based therapies, such as gemcitabine. Thus, CDA overexpression is often associated with lower systemic, chemotherapy-related, adverse...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytidine Deaminase
Share to Disease Susceptibility

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Expression Regulation

Share to Genetic Loci

Share to Genetic Predisposition to Disease

Share to Genetic Structures

Share to Genetic Therapy

Share to Structure-Activity Relationship

Source

Open in PubMed Open full text

Identifiers

PMID: 31870623
DOI: 10.1016/j.ymthe.2019.11.026
PMCID: PMC7001087

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Emerging Role of Cytidine Deaminase in Human Diseases: A New Opportunity for Therapy?PMID 31870623Read ↗

Role of cytidine deaminase in toxicity and efficacy of nucleosidic analogs.Semantic proximity Read ↗

Cytidine deaminase protects pancreatic cancer cells from replicative stress and drives resistance to DNA-targeting drugsSemantic proximity Read ↗

Cytidine Deaminase Axis Modulated by miR-484 Differentially Regulates Cell Proliferation and Chemoresistance in Breast CancerSemantic proximity Read ↗

Cytidine deaminase-dependent mitochondrial biogenesis as a potential vulnerability in pancreatic cancer cellsSemantic proximity Read ↗

Regulation of deoxynucleotide metabolism in cancer: novel mechanisms and therapeutic implications.Semantic proximity Read ↗

Determination of common genetic variants in cytidine deaminase (CDA) gene in Indian ethnic population.Semantic proximity Read ↗

[Genomic mutator Activation-induced cytidine deaminase (AID) as a therapeutic target].Semantic proximity Read ↗

High-resolution melting analysis of sequence variations in the cytidine deaminase gene (CDA) in patients with cancer treated with gemcitabine.Semantic proximity Read ↗

Cytidine deaminase activity increases in the blood of breast cancer patients.Semantic proximity Read ↗

Cleavage of CAD by caspase-3 determines the cancer cell fate during chemotherapySemantic proximity Read ↗

DCTPP1: A promising target in cancer therapy and prognosis through nucleotide metabolismSemantic proximity Read ↗

More Than a Metabolic Enzyme: MTHFD2 as a Novel Target for Anticancer Therapy?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.