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Article

Targeting DNA Damage Response and Replication Stress in Pancreatic Cancer

9 Oct 2020

Abstract excerpt

BACKGROUND & AIMS: Continuing recalcitrance to therapy cements pancreatic cancer (PC) as the most lethal malignancy, which is set to become the second leading cause of cancer death in our society. The study aim was to investigate the association between DNA damage response (DDR), replication stress, and novel therapeutic response in PC to develop a biomarker-driven therapeutic strategy targeting DDR and...

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Identifiers

PMID: 33039466
DOI: 10.1053/j.gastro.2020.09.043

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