Article
APOBEC3A and APOBEC3B Activities Render Cancer Cells Susceptible to ATR Inhibition.
Cancer research - 1 Sept 2017
Buisson Rémi, Lawrence Michael S, Benes Cyril H, Zou Lee
Abstract excerpt
The apolipoprotein B mRNA editing enzyme catalytic polypeptide-like APOBEC3A and APOBEC3B have emerged as key mutation drivers in cancer. Here, we show that APOBEC3A and APOBEC3B activities impose a unique type of replication stress by inducing abasic sites at replication forks. In contrast to cells under other types of replication stress, APOBEC3A-expressing cells were selectively sensitive to ATR inhibitors...
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