Article

Polygenic Prediction via Bayesian Regression and Continuous Shrinkage Priors

2018-09-14

Abstract excerpt

Polygenic prediction has shown promise in identifying individuals at high risk for complex diseases, and may become clinically useful as the predictive performance of polygenic risk scores (PRS) improves. Here, we present PRS-CS, a novel polygenic prediction method that infers posterior SNP effect sizes using GWAS summary statistics and an external linkage disequilibrium (LD) reference panel. PRS-CS utilizes a hig...

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Literature Corpus work: 9bcbe5d7-c5f0-59b0-b47d-e251dcbc23e6
DOI: 10.1101/416859

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