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Article

Comparison of methods for building polygenic scores for diverse populations.

HGG advances - 9 Jan 2025

Gunn Sophia, Wang Xin, Posner Daniel C, Cho Kelly, Huffman Jennifer E, Gaziano Michael, Wilson Peter W, Sun Yan V, Peloso Gina, Lunetta Kathryn L

Abstract excerpt

Polygenic scores (PGSs) are a promising tool for estimating individual-level genetic risk of disease based on the results of genome-wide association studies (GWASs). However, their promise has yet to be fully realized because most currently available PGSs were built with genetic data from predominantly European-ancestry populations, and PGS performance declines when scores are applied to target populations...

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PMID: 39323095
DOI: 10.1016/j.xhgg.2024.100355
PMCID: PMC11532986

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MVP

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