Article

Improving on polygenic scores across complex traits using select and shrink with summary statistics

2022-09-17

Abstract excerpt

<h4>Structured Abstract</h4> <h4>Motivation</h4> As precision medicine advances, polygenic scores (PGS) have become increasingly important for clinical risk assessment. Many methods have been developed to create polygenic models with increased accuracy for risk prediction. Our select and shrink with summary statistics (S4) PGS method extends a previous method (polygenic risk score – continuous shrinkage (PRS-CS))...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4c4cfd86-58f3-5523-86ea-2d26fbbc8ce7
DOI: 10.1101/2022.09.13.22278911

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Improving on polygenic scores across complex traits using select and shrink with summary statisticsDOI 10.1101/2022.09.13.22278911Read

Improving on polygenic scores across complex traits using select and shrink with summary statistics (S4) and LDpred2.Semantic proximity Read

Polygenic Prediction via Bayesian Regression and Continuous Shrinkage PriorsSemantic proximity Read

Improving reporting standards for polygenic scores in risk prediction studies.Semantic proximity Read

Integrative polygenic risk score improves the prediction accuracy of complex traits and diseasesSemantic proximity Read

PGS-Depot: a comprehensive resource for polygenic scores constructed by summary statistics based methods.Semantic proximity Read

Optimizing and benchmarking polygenic risk scores with GWAS summary statisticsSemantic proximity Read

Polygenic risk score prediction accuracy convergenceSemantic proximity Read

The Polygenic Score Catalog: an open database for reproducibility and systematic evaluationSemantic proximity Read

Genetic prediction of complex traits with polygenic scores: a statistical review.Semantic proximity Read

Prediction of Polygenic Risks by Screening Thousands of Polygenic ScoresSemantic proximity Read

S4-Multi: enhancing polygenic score prediction in ancestrally diverse populationsSemantic proximity Read

<i>PGSFusion</i> streamlines polygenic score construction and epidemiological applications in biobank-scale cohortsSemantic proximity Read