Article

Epigenomic anomalies in induced pluripotent stem cells from Alzheimer’s disease cases

2024-08-30

Abstract excerpt

<h4>SUMMARY</h4> Reprogramming of adult somatic cells into induced pluripotent stem cells (iPSCs) resets the aging clock. However, primed iPSCs can retain cell-of-origin epigenomic marks, especially those linked to heterochromatin and lamina-associated regions. Here we show that iPSCs produced from dermal fibroblasts of late-onset sporadic Alzheimer’s disease (AD) cases retain epigenomic anomalies that supersede...

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Literature Corpus work: 4bfbe94b-2727-58aa-b765-99dd9740a514
DOI: 10.1101/2024.08.29.610372

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