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Article

CHCHD10 Mitigates Alzheimer's Disease-Related Phenotypes in Association With Epigenetic Remodeling in Directly Reprogrammed Neurons.

Advanced science (Weinheim, Baden-Wurttemberg, Germany) - 1 Sept 2026

Thomas Teresa M, Yang Ching-Yao, Zhang Kexin, Wetzel Liam, Bugybayeva Dina, Ferguson Julia, Hasan Md Mahmudul, Samsa William, Patil Nandita, Dash Anshul, Gowda Tarini, Zhu Xiongwei, Cheng Feixiong, Liu Tian

Abstract excerpt

Mitochondrial dysfunction and chromatin dysregulation are interconnected contributors to neuronal vulnerability in Alzheimer's disease (AD), yet the molecular mechanisms linking these processes remain poorly understood. CHCHD10, a mitochondrial intermembrane space protein, has been implicated in neurodegenerative disorders, but its role in AD has not been defined. Here, we identify CHCHD10 as a previously...

Read the complete abstract on PubMed

Topics

Humans
Alzheimer Disease
Epigenesis, Genetic
Neurons
Mitochondrial Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

DNA Methylation

Phenotype

Cellular Reprogramming

Source

Open in PubMed Open full text

Identifiers

PMID: 42348392
DOI: 10.1002/advs.76205
PMCID: PMC13337126

Genes

CHCHD10
ABCA7
KATNAL2
MAPT

Provenance

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