Article

Dedifferentiation orchestrated through remodeling of the chromatin landscape defines <i>PSEN1</i> mutation-induced Alzheimer’s Disease

2019-01-29

Abstract excerpt

Early-Onset Familial Alzheimer’s Disease (EOFAD) is a dominantly inherited neurodegenerative disorder elicited by mutations in the PSEN1 , PSEN2 , and APP genes 1 . Hallmark pathological changes and symptoms observed, namely the accumulation of misfolded Amyloid-β (Aβ) in plaques and Tau aggregates in neurofibrillary tangles associated with memory loss and cognitive decline, are understood to be temporally acc...

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Literature Corpus work: 026264ac-af4a-5e16-aeaf-ef5da66fc01a
DOI: 10.1101/531202

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