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Article

DNA methylation analysis on purified neurons and glia dissects age and Alzheimer's disease-specific changes in the human cortex.

Epigenetics & chromatin - 25 Jul 2018

Gasparoni Gilles, Bultmann Sebastian, Lutsik Pavlo, Kraus Theo F J, Sordon Sabrina, Vlcek Julia, Dietinger Vanessa, Steinmaurer Martina, Haider Melanie, Mulholland Christopher B, Arzberger Thomas, Roeber Sigrun, Riemenschneider Matthias, Kretzschmar Hans A, Giese Armin, Leonhardt Heinrich, Walter Jörn

Abstract excerpt

BACKGROUND: Epigenome-wide association studies (EWAS) based on human brain samples allow a deep and direct understanding of epigenetic dysregulation in Alzheimer's disease (AD). However, strong variation of cell-type proportions across brain tissue samples represents a significant source of data noise. Here, we report the first EWAS based on sorted neuronal and non-neuronal (mostly glia) nuclei from postmortem...

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Identifiers

PMID: 30045751
DOI: 10.1186/s13072-018-0211-3
PMCID: PMC6058387

Genes

ANK1
ADAM17
APP
CLU
CXXC5
HOXA3
MAP2
NCOR2
RAI1
SYNJ2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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