Article

Alzheimer's Disease as the Result of Aberrant Reactivation of Embryonic Brain Pathways Silenced Decades Earlier

2026-07-22

Abstract excerpt

<title>Abstract</title> <p>Background A fundamental mystery in Alzheimer's disease (AD) is why established adult axonal networks undergo progressive "dying-back" axopathy. During embryogenesis, axon growth is governed by a volatile molecular oscillator balancing outward-pushing Arp2/3 branched actin waves and inward contractile non-muscle actomyosin forces. We hypothesize that chronic aging stress causes epigene...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 76fa2a36-360a-53e1-9f80-bd41e677b376
DOI: 10.21203/rs.3.rs-10436661/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Alzheimer's Disease as the Result of Aberrant Reactivation of Embryonic Brain Pathways Silenced Decades EarlierDOI 10.21203/rs.3.rs-10436661/v1Read

Aged brain multi-omic integration captures immunometabolic and sex variationSemantic proximity Read

Spatial Transcriptomic Evidence Consistent with Reactivation of Embryonic Neural Pathways in Amyotrophic Lateral SclerosisSemantic proximity Read

Dedifferentiation and neuronal repression define familial Alzheimer's disease.Semantic proximity Read

Single-nucleus multiomics in brains from Hispanic individuals reveal<i>APOE-ε4</i>-driven disruption of focal adhesion signaling in the presence of cerebrovascular pathologySemantic proximity Read

Dedifferentiation orchestrated through remodeling of the chromatin landscape defines <i>PSEN1</i> mutation-induced Alzheimer’s DiseaseSemantic proximity Read

Spatial and single-nucleus transcriptomic analysis of genetic and sporadic forms of Alzheimer’s diseaseSemantic proximity Read

Conserved cell-type specific signature of resilience to Alzheimer’s disease nominates role for excitatory intratelencephalic cortical neuronsSemantic proximity Read

Compensatory Plasticity Defines a Vulnerable Neuronal State in Alzheimer’s Disease with PsychosisSemantic proximity Read

A Multi-omic Atlas of Human Choroid Plexus in Alzheimer’s DiseaseSemantic proximity Read

Single-Nucleus Transcriptomics Analysis Identifies Sex-Dichotomous Pathological Axes in Alzheimer’s Disease: Female Homeostatic Failure versus Male Neuroimmune ActivationSemantic proximity Read

Pseudotime analysis of 2,106 brains across nine regions reveals conserved immune, neuronal, and myelin regulatory programs in Alzheimer's diseaseSemantic proximity Read

A roadmap to human hippocampal neurogenesis in adulthood, aging and AD.Semantic proximity Read