Article
Dedifferentiation and neuronal repression define familial Alzheimer's disease.
Science advances - 1 Nov 2020
Caldwell Andrew B, Liu Qing, Schroth Gary P, Galasko Douglas R, Yuan Shauna H, Wagner Steven L, Subramaniam Shankar
Abstract excerpt
Identifying the systems-level mechanisms that lead to Alzheimer's disease, an unmet need, is an essential step toward the development of therapeutics. In this work, we report that the key disease-causative mechanisms, including dedifferentiation and repression of neuronal identity, are triggered by changes in chromatin topology. Here, we generated human induced pluripotent stem cell (hiPSC)-derived neurons from...
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