Article

A new set of DNA methylation variants in the human genome show predominant tissue-specificity and sensitivity to reprogramming with a potential for disease susceptibility

2026-07-21

Abstract excerpt

Analyses of 3,370 normal human tissues of ectodermal, endodermal and mesodermal origins identified 12,587 regions averaging ∼585 bp with significant differences in DNA methylation levels within identical tissues. These methylation variants (MeVars) occurred in 8,037 genes enriched in neurological disorders and cancers of which, majority were tissue-specific rather than being systemic. This somatic variation was re...

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Literature Corpus work: b670e270-7970-532b-abff-2ca96d2e7878
DOI: 10.64898/2026.07.18.738653

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