Article

Influence of genetic variants on gene expression in human pancreatic islets – implications for type 2 diabetes

2019-05-31

Abstract excerpt

Most signals detected by genome-wide association studies map to non-coding sequence and their tissue-specific effects influence transcriptional regulation. However, many key tissues and cell-types required for appropriate functional inference are absent from large-scale resources such as ENCODE and GTEx. We explored the relationship between genetic variants influencing predisposition to type 2 diabetes (T2D) and r...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4bdbfcad-4204-54f6-9755-d4aa3ec6ea52
DOI: 10.1101/655670

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Influence of genetic variants on gene expression in human pancreatic islets – implications for type 2 diabetesDOI 10.1101/655670Read

Genetic variant effects on gene expression in human pancreatic islets and their implications for T2D.Semantic proximity Read

TIGER: The gene expression regulatory variation landscape of human pancreatic islets.Semantic proximity Read

TIGER: The gene expression regulatory variation landscape of human pancreatic isletsSemantic proximity Read

Genetic regulatory signatures underlying islet gene expression and type 2 diabetes.Semantic proximity Read

Transcript Expression Data from Human Islets Links Regulatory Signals from Genome-Wide Association Studies for Type 2 Diabetes and Glycemic Traits to Their Downstream Effectors.Semantic proximity Read

Cell type-specific eQTL detection from single-cell RNA-seq reveals post-transcriptional regulatory mechanisms in human isletsSemantic proximity Read

Rare Non-coding Variation Identified by Large Scale Whole Genome Sequencing Reveals Unexplained Heritability of Type 2 DiabetesSemantic proximity Read

From Genetic Association to Molecular Mechanisms for Islet-cell Dysfunction in Type 2 Diabetes.Semantic proximity Read

Genetic regulation of RNA splicing in human pancreatic isletsSemantic proximity Read

A multi-omic integrative scheme characterizes tissues of action at loci associated with type 2 diabetesSemantic proximity Read

Genetic regulation of RNA splicing in human pancreatic isletsSemantic proximity Read

Single cell chromatin accessibility reveals pancreatic islet cell type- and state-specific regulatory programs of diabetes riskSemantic proximity Read