Article
Genetic variant effects on gene expression in human pancreatic islets and their implications for T2D.
Nature communications - 30 Sept 2020
Viñuela Ana, Varshney Arushi, van de Bunt Martijn, Prasad Rashmi B, Asplund Olof, Bennett Amanda, Boehnke Michael, Brown Andrew A, Erdos Michael R, Fadista João, Hansson Ola, Hatem Gad, Howald Cédric, Iyengar Apoorva K, Johnson Paul, Krus Ulrika, MacDonald Patrick E, Mahajan Anubha, Manning Fox Jocelyn E, Narisu Narisu, Nylander Vibe, Orchard Peter, Oskolkov Nikolay, Panousis Nikolaos I, Payne Anthony, Stitzel Michael L, Vadlamudi Swarooparani, Welch Ryan, Collins Francis S, Mohlke Karen L, Gloyn Anna L, Scott Laura J, Dermitzakis Emmanouil T, Groop Leif, Parker Stephen C J, McCarthy Mark I
Abstract excerpt
Most signals detected by genome-wide association studies map to non-coding sequence and their tissue-specific effects influence transcriptional regulation. However, key tissues and cell-types required for functional inference are absent from large-scale resources. Here we explore the relationship between genetic variants influencing predisposition to type 2 diabetes (T2D) and related glycemic traits, and human...
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