Article

Cell type-specific eQTL detection from single-cell RNA-seq reveals post-transcriptional regulatory mechanisms in human islets

2025-01-24

Abstract excerpt

Gene regulatory networks (GRN) must be robust to maintain cellular identity across individuals yet flexible to accommodate population genetic variants. Therefore, comparing expression quantitative trait loci (eQTL) in health and disease can reveal hidden players in GRN and post-transcriptional regulation. Here, we developed a computational pipeline to investigate the gain and loss of eQTLs in the 3’ untranslated r...

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Literature Corpus work: dffef152-8e6e-5d76-91aa-a96318667ef9
DOI: 10.1101/2025.01.21.633530

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