Genetic regulatory signatures underlying islet gene expression and type 2 diabetes.

doi:10.1073/pnas.1621192114

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Article

Genetic regulatory signatures underlying islet gene expression and type 2 diabetes.

Proceedings of the National Academy of Sciences of the United States of America - 28 Feb 2017

Varshney Arushi, Scott Laura J, Welch Ryan P, Erdos Michael R, Chines Peter S, Narisu Narisu, Albanus Ricardo D'O, Orchard Peter, Wolford Brooke N, Kursawe Romy, Vadlamudi Swarooparani, Cannon Maren E, Didion John P, Hensley John, Kirilusha Anthony, Bonnycastle Lori L, Taylor D Leland, Watanabe Richard, Mohlke Karen L, Boehnke Michael, Collins Francis S, Parker Stephen C J, Stitzel Michael L

Abstract excerpt

Genome-wide association studies (GWAS) have identified >100 independent SNPs that modulate the risk of type 2 diabetes (T2D) and related traits. However, the pathogenic mechanisms of most of these SNPs remain elusive. Here, we examined genomic, epigenomic, and transcriptomic profiles in human pancreatic islets to understand the links between genetic variation, chromatin landscape, and gene expression in the...

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Identifiers

PMID: 28193859
DOI: 10.1073/pnas.1621192114
PMCID: PMC5338551

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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