Article

Rare Non-coding Variation Identified by Large Scale Whole Genome Sequencing Reveals Unexplained Heritability of Type 2 Diabetes

2020-11-16

Abstract excerpt

Type 2 diabetes is increasing in all ancestry groups 1 . Part of its genetic basis may reside among the rare (minor allele frequency <0.1%) variants that make up the vast majority of human genetic variation 2 . We analyzed high-coverage (mean depth 38.2x) whole genome sequencing from 9,639 individuals with T2D and 34,994 controls in the NHLBI’s Trans-Omics for Precision Medicine (TOPMed) program 2 to show that...

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Literature Corpus work: 2b99e9f2-d3e3-568c-b018-689a04e5eeed
DOI: 10.1101/2020.11.13.20221812

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