TIGER: The gene expression regulatory variation landscape of human pancreatic islets.

doi:10.1016/j.celrep.2021.109807

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TIGER: The gene expression regulatory variation landscape of human pancreatic islets.

Cell reports - 12 Oct 2021

Alonso Lorena, Piron Anthony, Morán Ignasi, Guindo-Martínez Marta, Bonàs-Guarch Sílvia, Atla Goutham, Miguel-Escalada Irene, Royo Romina, Puiggròs Montserrat, Garcia-Hurtado Xavier, Suleiman Mara, Marselli Lorella, Esguerra Jonathan L S, Turatsinze Jean-Valéry, Torres Jason M, Nylander Vibe, Chen Ji, Eliasson Lena, Defrance Matthieu, Amela Ramon, Mulder Hindrik, Gloyn Anna L, Groop Leif, Marchetti Piero, Eizirik Decio L, Ferrer Jorge, Mercader Josep M, Cnop Miriam, Torrents David

Abstract excerpt

Genome-wide association studies (GWASs) identified hundreds of signals associated with type 2 diabetes (T2D). To gain insight into their underlying molecular mechanisms, we have created the translational human pancreatic islet genotype tissue-expression resource (TIGER), aggregating >500 human islet genomic datasets from five cohorts in the Horizon 2020 consortium T2DSystems. We impute genotypes using four...

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PMID: 34644572
DOI: 10.1016/j.celrep.2021.109807
PMCID: PMC8864863

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CCND2
SLC30A8

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