Article

Genetic regulation of RNA splicing in human pancreatic islets

2021-11-13

Abstract excerpt

Genetic variants that influence transcriptional regulation in pancreatic islets play a major role in the susceptibility to type 2 diabetes (T2D). For many susceptibility loci, however, the mechanisms are unknown. We examined splicing QTLs (sQTLs) in islets from 399 donors and observed that genetic variation has a widespread influence on splicing of genes with important functions in islet biology. In parallel, we p...

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Literature Corpus work: 1d4b1845-699c-5124-926a-42eef6778ef3
DOI: 10.1101/2021.11.11.468254

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