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Genetic regulation of RNA splicing in human pancreatic islets

15 Sept 2022

Abstract excerpt

BACKGROUND: Non-coding genetic variants that influence gene transcription in pancreatic islets play a major role in the susceptibility to type 2 diabetes (T2D), and likely also contribute to type 1 diabetes (T1D) risk. For many loci, however, the mechanisms through which non-coding variants influence diabetes susceptibility are unknown. RESULTS: We examine splicing QTLs (sQTLs) in pancreatic islets from 399 human...

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PMID: 36109769
DOI: 10.1186/s13059-022-02757-0

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