Article

TIGER: The gene expression regulatory variation landscape of human pancreatic islets

2021-05-27

Abstract excerpt

GWAS have identified more than 700 genetic signals associated with type 2 diabetes (T2D). To gain insight into the underlying molecular mechanisms, we created the Translational human pancreatic Islet Genotype tissue-Expression Resource (TIGER), aggregating >500 human islet RNA-seq and genotyping datasets. We imputed genotypes using 4 reference panels and meta-analyzed cohorts to improve coverage of expression quan...

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Literature Corpus work: 6cc0a8a3-7cc3-596e-89a4-3e171b9c06db
DOI: 10.1101/2021.05.26.445616

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