Article

APOBEC3B coordinates R-loop to promote replication stress and sensitize cancer cells to ATR/Chk1 inhibitors

2023-02-02

Abstract excerpt

<title>Abstract</title> <p>The cytidine deaminase, Apolipoprotein B mRNA editing enzyme catalytic subunit 3B (APOBEC3B, herein termed A3B), is a critical mutation driver that induces genomic instability in cancer by catalyzing cytosine-to-thymine (C-to-T) conversion and promoting replication stress. However, the detailed function of A3B in replication stress is not fully determined and it is not known whether the...

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Literature Corpus work: 4ba20846-8aef-5351-9b40-3c63a4c84261
DOI: 10.21203/rs.3.rs-2424454/v1

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