Article

Genetic modifiers of APOBEC-induced mutagenesis

2023-04-06

Abstract excerpt

The cytidine deaminases APOBEC3A and APOBEC3B (A3B) are prominent mutators of human cancer genomes. However, tumor-specific genetic modulators of APOBEC-induced mutagenesis are poorly defined. Here, we utilized a screen to identify 61 gene deletions that increase A3B-induced mutations in yeast. Also, we determined whether each deletion was epistatic with UNG1 loss, which indicated whether the encoded factors parti...

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Literature Corpus work: 75bdea4e-41d2-5163-8e4f-7053979ca962
DOI: 10.1101/2023.04.05.535598

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