Article
APOBEC3B coordinates R-loop to promote replication stress and sensitize cancer cells to ATR/Chk1 inhibitors.
Cell death & disease - 3 Jun 2023
Zong Chunyan, Zhang Zhe, Gao Li, He Jie, Wang Yiran, Li Qian, Liu Xiaoting, Yang Jie, Chen Di, Huang Rui, Zheng Guopei, Jin Xiaoliang, Wei Wu, Jia Renbing, Shen Jianfeng
Abstract excerpt
The cytidine deaminase, Apolipoprotein B mRNA editing enzyme catalytic subunit 3B (APOBEC3B, herein termed A3B), is a critical mutation driver that induces genomic instability in cancer by catalyzing cytosine-to-thymine (C-to-T) conversion and promoting replication stress (RS). However, the detailed function of A3B in RS is not fully determined and it is not known whether the mechanism of A3B action can be...
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