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APOBEC3A damages the cellular genome during DNA replication

26 Feb 2016

Abstract excerpt

The human APOBEC3 family of DNA-cytosine deaminases comprises 7 members (A3A-A3H) that act on single-stranded DNA (ssDNA). The APOBEC3 proteins function within the innate immune system by mutating DNA of viral genomes and retroelements to restrict infection and retrotransposition. Recent evidence suggests that APOBEC3 enzymes can also cause damage to the cellular genome. Mutational patterns consistent with...

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PMID: 26918916
DOI: 10.1080/15384101.2016.1152426

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