Article

R-loop editing by DNA cytosine deaminase APOBEC3B determines the activity of estrogen receptor enhancers

2022-10-22

Abstract excerpt

<h4>Summary</h4> Estrogen receptor (ER) activation results in the formation of DNA double strand breaks (DSB), which promote genomic instability and tumour heterogeneity in ER-positive breast cancers. The single-stranded DNA (ssDNA) cytosine deaminase APOBEC3B (A3B) regulates ER activity by inducing DSB at ER enhancers. To delineate how A3B recognises its substrates and unveil the underlying mechanism leading to...

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Literature Corpus work: c13c7a1f-2fb2-5a22-90c5-209cbf18dff5
DOI: 10.1101/2022.10.21.513235

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