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Guardian ubiquitin E3 ligases target cancer-associated APOBEC3 deaminases for degradation to promote human genome integrity

2024-04-26

Abstract excerpt

<h4>Highlights</h4> RNA-free APOBEC3 (A3) can enter the nucleus, leading to genomic mutations. Three E3 ligases specifically bind the RNA-binding domain of nuclear A3s. Cancer-associated A3B and A3H-I are thereby targeted for proteasomal degradation. These E3 ligases thus act as genome guardians by limiting A3-mediated mutagenesis. APOBEC family members play crucial roles in antiviral restriction. However, certai...

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Literature Corpus work
a82228ca-04b5-5019-a863-408c659faad1
DOI
10.1101/2024.04.23.590688
Open publication

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Guardian ubiquitin E3 ligases target cancer-associated APOBEC3 deaminases for degradation to promote human genome integrityDOI 10.1101/2024.04.23.590688
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