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Article

APOBEC-1 cofactors regulate APOBEC3-induced mutations in hepatitis B virus.

Journal of virology - 25 Feb 2025

Chen Zhigang, Eggerman Thomas L, Bocharov Alexander V, Baranova Irina N, Vishnyakova Tatyana G, Patterson Amy P

Abstract excerpt

APOBEC3 proteins (A3s) play an important role in host innate immunity against viruses and DNA mutations in cancer. A3s-induced mutations in both viral and human DNA genomes vary significantly from non-lethal mutations in viruses to localized hypermutations, such as kataegis in cancer. How A3s are regulated remains largely unknown. Since A3s exist in complexes and belong to the same family as APOBEC-1 (A1), which...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39868801
DOI: 10.1128/jvi.01879-24
PMCID: PMC11853063

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